Propofol Related Infusion Syndrome (PRIS)

• cardiac failure, arrhythmias

• rhabdomyolysis

• metabolic acidosis, unexplained lactic acidosis

• kidney failure

• often fatal

• hyperkalemia

• high triglycerides

• hepatomegaly

• green urine (some sources say there is no correlation with PRIS)

• proposed to be caused by either "a direct mitochondrial respiratory chain inhibition or impaired mitochondrial fatty acid metabolism"

• more commonly in children, and critically ill patients receiving catecholamines and glucocorticoids are at high risk

• Treatment

  • supportive

  • pacing

  • adequate carbohydrate intake (6-8mg/kg/min)

  • carnitine supplementation (theoretical benefit)