Gastrointestinal Stromal Tumors (GIST)

last updated: Apirl 21, 2016

  • most common mesenchymal neoplasms of the gastrointestinal tract.

  • GISTs arise in the smooth muscle pacemaker interstitial cell of Cajal, or similar cells

  • They are defined as tumors whose behavior is driven by mutations in the KIT gene (85%), PDGFRA gene (10%), or BRAF kinase (rare).

  • 95% of GISTs stain positively for KIT (CD117).

  • Most (66%) occur in the stomach and gastric GISTs have a lower malignant potential than tumors found elsewhere in the GI tract

  • ulcerations on these tumors can represent tumor necrosis and known marker of malignant behavior

  • these tumors tend to bleed easily after biopsy

Signs / Symptoms 

  • dyspepsia

... but I would more especially commend the clinician who, in acute diseases, by which the bulk of mankind are cutoff, conducts the treatment better than others.
 
Hippocrates, 400 BC