Thiazide-Like Diuretic


Metolazone (Zaroxolyn)

  • usually used in combination with loop diuretics

  • targets tjhe distal convoluted tubule inhibiting the Na-Cl symporter

  • ten times as potent as hydrochlorothiazide

  • 14 hour half-life

... but I would more especially commend the clinician who, in acute diseases, by which the bulk of mankind are cutoff, conducts the treatment better than others.
Hippocrates, 400 BC